The Binding of Isaac: Rebirth adventure archiveThe Binding of Isaac: RebirthGUIDES
The Binding of Isaac: Rebirth / Items

Isaac Rebirth items guide: active items and useful passives

Recognize common item roles and distinguish original Rebirth effects from later expansion changes.

Edition covered

Original PC Rebirth base game without Afterbirth, Afterbirth+, Repentance or Repentance+. DLC characters, modern room types, expansion bosses and changed Lost unlock rules are outside these guides. Publisher media is from the Rebirth Steam listing.

3 items · one picture per entry · open a picture for full size.

Separate active tools from passive effects

Book of Belial in The Binding of Isaac: Rebirth
Basic action: Increase damage for the room

Book of Belial

Use it when: A boss or crowded encounter needs faster clearing.

Reference

The D6 in The Binding of Isaac: Rebirth
Basic action: Reroll item pedestals in the room

The D6

Use it when: An available pedestal is worth changing.

Reference

Read passive changes before judging a synergy

Brimstone in The Binding of Isaac: Rebirth
Replace tears with a charged beam

Brimstone

Change to notice: Charge safely before lining up the beam.

Reference

More items

  • Yum Heart — Restore one Red Heart · A red container has missing health
  • The Poop — Create a poop obstacle · You want its breakable obstacle and possible contents
  • Spoon Bender — Homing tears · Shots curve toward enemies
  • Mutant Spider — Four tears per shot with slower firing · A wider volley and longer gap
  • Magic Mushroom — Health and several stat improvements · A broader stat boost rather than a new firing mode

Quick notes

  • Separate active tools from passive effects. An active item occupies the usable item slot and normally needs charge to work again.
  • Read passive changes before judging a synergy. A passive can alter tear behavior rather than simply raising damage.
  • Treat a strong pickup as part of a build. Spoon Bender adds homing, while Mutant Spider creates a wider multi-shot pattern with a slower firing rhythm.
  • Use the right edition reference. Rebirth, Afterbirth and Repentance can give the same named item different interactions.
Useful tip

An unfamiliar item can change the timing of your attacks. Test it in the cleared room before opening the next door.

References
Guide references
ReferenceWebsite
Yum Heartbindingofisaacrebirth.wiki.gg
The Book of Belialbindingofisaacrebirth.wiki.gg
The D6bindingofisaacrebirth.wiki.gg
The Poopbindingofisaacrebirth.wiki.gg
Spoon Benderbindingofisaacrebirth.wiki.gg
Mutant Spiderbindingofisaacrebirth.wiki.gg
Brimstonebindingofisaacrebirth.wiki.gg
Magic Mushroombindingofisaacrebirth.wiki.gg