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The Binding of Isaac: Rebirth adventure archiveThe Binding of Isaac: RebirthGUIDES

The Binding of Isaac: Rebirth Guide

2014 · Roguelike dungeon crawler

Game guides

Find the guide you need
GuideWhat you will find
The player and a small blue companion face several enemies among rocks in a brown dungeon room.Getting startedMake useful room choices, preserve keys and understand health in the original Rebirth base game.
The player and a small blue companion face several enemies among rocks in a brown dungeon room.CharactersCompare practical base-game character unlocks and the changes they make to an early run.
The Mutant Spider pickup banner reads Quad shot above the player in a treasure room.ItemsRecognize common item roles and distinguish original Rebirth effects from later expansion changes.
A red beam runs vertically through a brown dungeon room while the health, pickups and minimap remain visible.Secret roomsUse room geometry to find ordinary Secret Rooms and distinguish Super Secret Rooms.
A curved purple beam crosses a gray dungeon room containing enemies and obstacles.ProgressionFollow major original-game unlock milestones without importing DLC routes or bosses.

At a glance

Three useful starting points
FocusWhat to know
Choose a run objectiveAim for a character unlock or a specific chapter before spending scarce resources.
Check item behaviorNew passives can change shot patterns, timing and the distance at which a build is comfortable.
Keep editions separateRebirth progression differs from the later expansion routes often shown in current videos.

Characters Character guide →

Key characters and their roles
CharacterRoleAt a glance
IsaacStarting characterThe basic playable character; gains the D6 start only after a separate unlock.
MagdaleneHealing-focused startUses Yum Heart and a larger initial red-health pool.
CainAlternative starterBegins with Lucky Foot and fires from one eye.
JudasDamage-focused startBegins with Book of Belial but little starting health.
AzazelFlying characterUses a short-range charged beam instead of normal tears.

Quick answers

Unlocks, routes and useful answers
TopicGo straight to
Getting startedRead the room before spending a key →
CharactersUse a concrete unlock target →
ItemsSeparate active tools from passive effects →
Secret roomsStart with the map, then inspect the walls →
ProgressionFollow the main chapter milestones →

Pictures All pictures →

A red beam runs vertically through a brown dungeon room while the health, pickups and minimap remain visible.
A red beam runs vertically through a brown dungeon room while the health, pickups and minimap remain visible.
A curved purple beam crosses a gray dungeon room containing enemies and obstacles.
A curved purple beam crosses a gray dungeon room containing enemies and obstacles.
The Mutant Spider pickup banner reads Quad shot above the player in a treasure room.
The Mutant Spider pickup banner reads Quad shot above the player in a treasure room.
The player and a small blue companion face several enemies among rocks in a brown dungeon room.
The player and a small blue companion face several enemies among rocks in a brown dungeon room.
References
Guide references
ReferenceWebsite
The Binding of Isaac: Rebirth: game and edition overviewbindingofisaacrebirth.wiki.gg