The Binding of Isaac: Rebirth / Characters
Isaac Rebirth characters: unlocks and starting playstyles
Compare practical base-game character unlocks and the changes they make to an early run.
Edition covered
Original PC Rebirth base game without Afterbirth, Afterbirth+, Repentance or Repentance+. DLC characters, modern room types, expansion bosses and changed Lost unlock rules are outside these guides. Publisher media is from the Rebirth Steam listing.
6 characters · one picture per entry · open a picture for full size.
Characters
Quick notes
- Use a concrete unlock target. Isaac is available on a new save.
- Choose a playstyle you can support. Starting items and health can make two characters feel very different with the same first pickup.
- Remember that Isaac does not start with the D6 immediately. The D6 becomes Isaac’s starting active item after defeating the Isaac boss as ???.
- Check edition-specific unlock instructions. The Lost has a particularly different unlock process in original Rebirth compared with later DLC.
Useful tip
Unlock requirements usually measure what happens in a single run or a specific boss clear; check the exact condition before trying to force it.