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The Binding of Isaac adventure archiveThe Binding of IsaacGUIDES

The Binding of Isaac Guide

2011 · Roguelike action

Game guides

Find the guide you need
GuideWhat you will find
Isaac fights several enemies in a blood-stained Basement 2 room.UnlocksExact early unlock requirements for the 2011 Flash edition.
A character fires a red beam across pits in a Cave 1 room.ItemsA selective original-edition reference for recognizable early items.
Isaac fights several enemies in a blood-stained Basement 2 room.RoomsUnderstand common room doors and resource decisions in the original Flash game.
Isaac faces a large round boss in a Cave 2 arena.BossesA selective boss reference for an original-edition first clear.
An in-game dream vignette shows Isaac imagining three other children.CharactersStarting equipment and health make these original-edition characters play differently even when they find the same item.

At a glance

Three useful starting points
FocusWhat to know
First clearBeat Mom to open the Womb on later runs.
First unlocksHold 55 coins for Cain or reach seven heart containers for Magdalene.
First priorityProtect health before spending it on an optional reward.

Characters Character guide →

Key characters and their roles
CharacterRoleAt a glance
IsaacStarting characterBegins with three red heart containers and a bomb.
MagdaleneUnlockable survivorStarts with four red heart containers and Yum Heart.
CainUnlockable survivorStarts with Lucky Foot, a key and two red heart containers.
JudasUnlockable survivorStarts with Book of Belial, three coins and one red heart container.
MomMajor bossThe first run-ending obstacle in Depths II.

Quick answers

Unlocks, routes and useful answers
TopicGo straight to
UnlocksOriginal character requirements →

Pictures All pictures →

Isaac fights several enemies in a blood-stained Basement 2 room.
Isaac fights several enemies in a blood-stained Basement 2 room.
A character fires a red beam across pits in a Cave 1 room.
A character fires a red beam across pits in a Cave 1 room.
Isaac faces a large round boss in a Cave 2 arena.
Isaac faces a large round boss in a Cave 2 arena.
An in-game dream vignette shows Isaac imagining three other children.
An in-game dream vignette shows Isaac imagining three other children.
References
Guide references
ReferenceWebsite
The Binding of Isaac: game and edition overviewstore.steampowered.com