Dead Cells rune locations: Vine, Teleportation, Ram and Spider
Follow the permanent movement-unlock chain and reach the Spider Rune without a circular route.
Edition covered
Modern PC base-game systems with free updates, including Rise of the Giant. Main route tables exclude paid DLC branches. Publisher images may come from earlier versions; balance values and platform update timing can differ.
Collect the main movement runes in order

These four runes open the core base-game route network. Defeat the elite in the special room and collect its rune. The unlock is immediate and permanent; you do not need to deliver it to the Collector.
| Rune | Location | Ability |
|---|---|---|
| Vine | Promenade of the Condemned | Grow climbable vines |
| Teleportation | Toxic Sewers | Use teleportation coffins |
| Ram | Ossuary | Break marked floors with a ground slam |
| Spider | Slumbering Sanctuary | Climb and cling to walls |
Use the correct route to the next rune
The first Spider Rune route goes through the sewers and Conjunctivius. Trying to enter Slumbering Sanctuary from a route that already needs wall climbing creates an unnecessary loop. The route below is designed for the initial unlock sequence.
| Target | Route from Prisoners’ Quarters | Earlier requirement |
|---|---|---|
| Vine | Promenade of the Condemned | No movement rune |
| Teleportation | Toxic Sewers | Vine |
| Ram | Promenade → Ossuary | Teleportation |
| Spider | Toxic Sewers → Ancient Sewers → Insufferable Crypt → Slumbering Sanctuary | Vine and Ram; defeat Conjunctivius |
Check the map for the special encounter
Layouts change between attempts, so a fixed left-or-right instruction is unreliable. Explore the target biome for the unique rune encounter and prepare before entering. Collecting the rune is the key milestone even if that run ends soon afterward.
Return to old biomes with new movement
Climbable walls, marked breakable floors and teleportation coffins become meaningful after the matching rune. Revisit a known exit when a new ability opens it. Later runes add other conveniences, but they are separate from these four traversal gates.
The Spider Rune is in Slumbering Sanctuary; reaching the biome and finding its elite room are separate steps.
References
| Reference | Website |
|---|---|
| Runes and upgrades | deadcells.wiki.gg |
| Toxic Sewers | deadcells.wiki.gg |
| Ossuary | deadcells.wiki.gg |
| Slumbering Sanctuary | deadcells.wiki.gg |
