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Dead Cells / Runes

Dead Cells rune locations: Vine, Teleportation, Ram and Spider

Follow the permanent movement-unlock chain and reach the Spider Rune without a circular route.

Edition covered

Modern PC base-game systems with free updates, including Rise of the Giant. Main route tables exclude paid DLC branches. Publisher images may come from earlier versions; balance values and platform update timing can differ.

Collect the main movement runes in order

Ranged attacks cross a green sewer chamber with poison pools and enemies on several levels.
Ranged attacks cross a green sewer chamber with poison pools and enemies on several levels.

These four runes open the core base-game route network. Defeat the elite in the special room and collect its rune. The unlock is immediate and permanent; you do not need to deliver it to the Collector.

Collect the main movement runes in order
RuneLocationAbility
VinePromenade of the CondemnedGrow climbable vines
TeleportationToxic SewersUse teleportation coffins
RamOssuaryBreak marked floors with a ground slam
SpiderSlumbering SanctuaryClimb and cling to walls

Use the correct route to the next rune

The first Spider Rune route goes through the sewers and Conjunctivius. Trying to enter Slumbering Sanctuary from a route that already needs wall climbing creates an unnecessary loop. The route below is designed for the initial unlock sequence.

Use the correct route to the next rune
TargetRoute from Prisoners’ QuartersEarlier requirement
VinePromenade of the CondemnedNo movement rune
TeleportationToxic SewersVine
RamPromenade → OssuaryTeleportation
SpiderToxic Sewers → Ancient Sewers → Insufferable Crypt → Slumbering SanctuaryVine and Ram; defeat Conjunctivius

Check the map for the special encounter

Layouts change between attempts, so a fixed left-or-right instruction is unreliable. Explore the target biome for the unique rune encounter and prepare before entering. Collecting the rune is the key milestone even if that run ends soon afterward.

Return to old biomes with new movement

Climbable walls, marked breakable floors and teleportation coffins become meaningful after the matching rune. Revisit a known exit when a new ability opens it. Later runes add other conveniences, but they are separate from these four traversal gates.

Useful tip

The Spider Rune is in Slumbering Sanctuary; reaching the biome and finding its elite room are separate steps.

References
Guide references
ReferenceWebsite
Runes and upgradesdeadcells.wiki.gg
Toxic Sewersdeadcells.wiki.gg
Ossuarydeadcells.wiki.gg
Slumbering Sanctuarydeadcells.wiki.gg