BioShock 2 Little Sisters: adopt, gather, rescue and Big Sister preparation
Understand ADAM collection and the choices that follow each Little Sister.
Edition covered
Original 2010 BioShock 2 single-player story and core systems. Cover art is from the original PC release; gallery pictures show the enhanced BioShock 2 Remastered campaign. Multiplayer and Minerva’s Den have separate content and are excluded.
Adopt to gather before the final choice

After dealing with her protector, a Little Sister can be adopted instead of harvested immediately. Carry her to suitable ADAM-bearing bodies, then protect her while she gathers.
| Step | Action | Purpose |
|---|---|---|
| Protector encounter | Defeat the Big Daddy when ready | Gain access to the Little Sister |
| Adoption | Carry the Little Sister | Enables ADAM gathering |
| Gathering | Place her at a highlighted suitable body | Earn ADAM while defending |
| Vent decision | Rescue or harvest | Resolve her fate and rewards |
| Big Sister warning | Prepare a defensible area | Meet a dangerous follow-up threat |
Prepare the room before setting her down
Gathering attracts attackers. Hack usable security, place Trap Rivets or other traps and identify a firing position with sight of the Little Sister before starting.
| Tool | Use | Placement idea |
|---|---|---|
| Trap Rivets | Damage approaching attackers | Likely approach lanes |
| Hacked turret | Automatic allied fire | A line covering the gathering area |
| Security bot | Mobile support | Bring it before starting |
| Electro Bolt | Briefly disable a threat | Interrupt an attacker near the Sister |
| First Aid and EVE | Maintain survival and powers | Refill before the fight |
Rescue and harvest are different decisions
At the appropriate vent, rescuing or harvesting resolves the Little Sister’s fate. The choice affects the story; gathering first is a separate activity from that final decision.
Use the Big Sister warning to prepare
Big Sister encounters follow progress with Little Sisters. When warned, replenish health, EVE and ammunition and choose a room with movement space rather than entering the fight in a narrow dead end.
Big Sister encounters follow progress with Little Sisters.
References
| Reference | Website |
|---|---|
| BioShock 2 publisher listing | store.steampowered.com |
| Official BioShock 2 PC manual | store.steampowered.com |
